De La Salle University occupies a 5.04 hectare lot along busy Taft Avenue in Manila. It is about four kilometers away from Manila's City Hall and is easily accessible by public transportation. Along this kilometer radius are situated other colleges and universities, a sports center complex, the Bangko Sentral ng Pilipinas, the Cultural Center of the Philippines complex, a row of four-and-five-star hotels, restaurants, shopping and entertainment centers, as well as main feeder roads. The rest of Metropolitan Manila and its environs are easily accessible by private or public transportation.
The University is also served by Manila's Light Rail Transit (LRT) which hastens the travel time of commuters. The proximity of the LRT stations (Pablo Ocampo Avenue [formerly known as Vito Cruz Ave.] - Quirino Avenue) to the University facilitates traveling via LRT.
By virtue of its location, De La Salle University has become an urban university sharing in the development growth, success, and the concomitant problems of a growing metropolis.
The University functions like a city with a population of about 13,000 made up of faculty members, administrators, students (college and graduate school), and support staff. Some large and small buildings consisting of the six classroom buildings - the La Salle Hall, Brother Miguel Hall, Saint Joseph Hall, Velasco Hall, Gokongwei Hall, Saint Mutien-Marie Hall - as well as the Gabriel Connon Hall, William Hall, the DLSU Sports Complex, the University Library Building, the Yuchengco Central Administration Building, and the Science and Technology Research Center (STRC) presently occupy this land area.
The atmosphere inside the campus, like that existing outside the University walls, is primarily urban in character. Eighty-five percent of the students come from the metropolitan area and close to 100 percent reside within the area. Moreover, the majority of students, coming as they do from the middle and higher socio-economic levels, expect to work in Metropolitan Manila or in similar urban areas. Because of this, the courses offered at De La Salle University - commerce, computer studies, education, engineering, liberal arts, and sciences - are urban in orientation.