ANGELYN R. LAO, Ph.D - De La Salle University

Angelyn R. Lao, Ph.D.

Several of her most notable publications include her work on establishing mathematical and compartmental models to describe and analyze biological and signaling pathways associated to different diseases. She also applies mathematical and computational models to study epidemic spreading of diseases and health communication dynamics. Her recent works apply mathematics to study and discover the patterns in the topological structures of different networks/graphs.

Dr. Angelyn R. Lao joined DLSU after the completion of her Doctorate degree in Systems Biology at the University of Rostock (Germany). She obtained her BS and MS degree in Mathematics at De La Salle University. She held two Professorial Chairs in Mathematics namely the Br. C. John Lynan FSC Professorial Chair in Mathematics and the Br. Albinus Peter FSC Professorial Chair in Mathematics. Several of her most notable publications include her work on establishing mathematical and compartmental models to describe and analyze biological and signaling pathways associated to different diseases. She also applies mathematical and computational models to study epidemic spreading of diseases and communication dynamics. Her recent works apply mathematics to study and discover the patterns in the topological structures of different networks/graphs.

Full Professor

Dr.-Ing. in Systems Biology and Bioinformatics

Systems Biology, Chemical Reaction Network Theory, Applied Mathematics

PUBLICATIONS

A. Lao, M.A. Dela Cruz, G.J. Tenio, P. Sy, E. Mendoza. Stochastic Process Algebra
Model of Amyloidogenic Processing in Alzheimer’s Disease. In: Abdul Karim S.A.,
Shafie A. (eds) Towards Intelligent Systems Modeling and Simulation. Studies in
Systems, Decision and Control, vol 383. Springer, Cham, 2022.
H. Farinas, E. Mendoza, and A. Lao. Chemical reaction network decompositions and
realizations of S-systems. Philippine Science Letters, 14(1), 2021.
N. Fortun, E. Mendoza, L. Razon and A. Lao. Robustness in Power-Law Kinetic
Systems with Reactant-Determined Interactions. In: Akiyama J., Marcelo R.M.,
Ruiz M.P., Uno Y. (eds) Discrete and Computational Geometry, Graphs, and Games.
JCDCGGG 2018, LNCS 13034, pp. 106–121, Springer, Switzerland, 2021.
A. Lao, J.M.C. Edra, K.D. Talag, D.S. Tan, G. Oyong, M. Noel, … & M.C. Tan. Cytotoxic
activity of Raphanus sativus Linn. On selected cancer cell lines and mechanistic
pathways predicted through mathematical modeling. In: Mohd M.H., Misro M.Y.,
Ahmad S., Nguyen Ngoc D. (eds) Modelling, Simulation and Applications of
Complex Systems. CoSMoS 2019. Springer Proceedings in Mathematics & Statistics,
vol 359. Springer, Singapore, 2021.
R.G. Tan, K. Aviso, A. Lao, M. Promentillo. Modelling vicious networks with P-
graph causality maps. Clean technologies and environmental policy, 1-12, 2021.
R.G. Tan, K. Aviso, A. Lao, M. Promentillo. P-graph Causality Maps. Process
Integration and Optimization for Sustainability, 1-16, 2021.
DOI : 10.1007/s41660-020-00147-2
K.J. Villasin, E. Rodriguez, and A. Lao. A Deterministic Compartmental Modeling
Framework for Disease Transmission. In: Marchisio M.A. (eds) Computational
Methods in Synthetic Biology. Methods in Molecular Biology, vol 2189. Humana,
New York, NY, 2021.
A. Laron, D.S. Tan, N.R. Lim-Cheng, M. Baclig, L. Cornista, M.L. Daroy, A. Lao, and
R. Batista-Navarro. Extraction and graph representation of disease-disease
associations from biomedical journals using support vector machines.
Manuscript submitted for publication, 2021.
K. Fields, N. Fortun, G.A. Solano, A. Lao. CRNet Translator: Building GMA, S-
System Models and Chemical Reaction Networks of Disease and Metabolic
Pathways. In 2020 11th International Conference on Information, Intelligence,
Systems and Applications (IISA), IEEE, 2020.
JM Recario, G.A. Solano, A. Lao. PlaPhy-SMD: A Database System of Plants and
their Phytochemicals Integrated with Small-Molecule Drugs and their Condition
and Gene Associations with Clustering and Product Ingredient Matching. In 2020
11th International Conference on Information, Intelligence, Systems and
Applications (IISA), IEEE, 2020.
A. Lucido, R. Smith, A. Lao. Prevention of H5N6 outbreaks in the Philippines using
optimal control. Philippine Science Letters, 13(2), 158-175, 2020.
A. Lao, U. Chua, B.P. Samson. Analysis of the co-authorship network of Filipino
researchers in deep learning. Philippine Science Letters, 13(2), 148-157, 2020.
H. Farinas, E. Mendoza, A. Lao. Structural Properties of an S-system Model of
Mycobacterium tuberculosis Gene Regulation. Philippine Journal of Science,
149(3), 539-563, 2020.
A. Lao, H. Cabezas, A. Orosz, F. Friedler, R. Tan. Socio-ecological network
structures from process graphs. PLoS ONE, 15(8), e0232384, 2020.
D.E. Sumalapao, L.E. Bagwan, A. Lao. Constrained Supply Chain Scheduling
Model Using Sequential Quadratic Programming Algorithm. Journal of Sciences,
Islamic Republic of Iran, 31(4), 349-356, 2020.
E. Briones, A. Lao, G.A. Solano. A Pancreatic Cancer Detection Support Tool Using
Mass Spectrometry Data and Support Vector Machines. 2020 International
Conference on Artificial Intelligence and Signal Processing, AISP 2020.
M. Feria, M. Oliva, B.P. Samson, and A. Lao. Drowning Out Rumor: Dynamical
Models of the Interaction between Spreaders of and Exposed to Truth and
Rumor Spreading. Philippine Journal of Science 148 (4), 659-686, 2019.
A. Nazareno, R.P. Eclarin, E. Mendoza and A. Lao. Linear conjugacy of chemical
kinetic systems. Mathematical Biosciences and Engineering, 16(6), 8322-8355,
2019.
C.P. Arceo, E. Jose, A. Lao, and E. Mendoza. Chemical Reaction Networks: Filipino
contributions to their theory and its Applications. Philippine Journal of Science,
148(2), 249-261, 2019.
N. Fortun, E. Mendoza, L. Razon and A. Lao. A Deficiency Zero Theorem for a class
of power-law kinetic systems with non-reactant-determined interactions.
MATCH Communication in Mathematical and Computer Chemistry, 81, 621-638,
2019.
D. Mendoza, A. Lao and G.A. Solano. Pathway based Human Disease Clustering
and Similarity Analysis Tool Using Frequent Structure Mining. In 2018 9th
International Conference on Information, Intelligence, Systems and Applications
(IISA), IEEE, 2018.
D. Rodriguez, A. Lao and G.A. Solano. Biological Network Analysis and
Subnetwork Extraction Tool. In 2018 9th International Conference on Information,
Intelligence, Systems and Applications (IISA), IEEE, 2018.
N. Fortun, E. Mendoza, L. Razon and A. Lao. A Deficiency-One Algorithm for
power-law kinetic systems with reactant-determined interactions. Journal of
Mathematical Chemistry, 56(10), 2929-2962, 2018.
N. Fortun, E. Mendoza, L. Razon and A. Lao. Multistationarity in Earth’s Pre-
industrial Carbon Cycle Models. Manila Journal of Science, 11, 81-96, 2018.
H. Lee and A. Lao. Transmission dynamics and control strategies assessment of
avian influenza A (H5N6) in the Philippines. Infectious Disease Modelling, 3, 35-
59, 2018.
C.P. Arceo, E. Jose, A. Lao, and E. Mendoza. Reactant subspaces and kinetics of
chemical reaction networks. Journal of Mathematical Chemistry, 56(2), 395-422,
2018.
D.S. Tan, R.N. Leong, A.F. Laguna, C.A. Ngo, A. Lao, D. Amalin, and D. Alvindia.
AuToDiDAC: Automated Tool for Disease Detection and Assessment for Cacao
Black Pod Rot. Crop Protection, 103, 98-102, 2018.
J. A. R. Sarmiento, A. Lao and G.A. Solano. Pathway-based human disease
clustering tool using self-organizing maps. 2017 8th International Conference on
Information, Intelligence, Systems & Applications (IISA), (pp. 1-6). IEEE, 2018.
C.P. Arceo, E. Jose, A. Lao, and E. Mendoza. Reaction networks and kinetics of
biochemical systems. Mathematical Biosciences, 283, 13-29, 2017.
K.J. Villasin, A. Lao, and E. Rodriguez. A dynamical analysis of Tuberculosis in the
Philippines. Philippine Science Letters, 10 (1), 29-37, 2017.
H. Alcantara, A. Lao, and L.Ruivivar. Stability Analysis of the ODE Model
Representation of Amyloidogenic Processing in Alzheimer’s Disease in the
Presence of SORLA. Mol. BioSyst., 2016. doi:10.1039/c5mb00741k.
DS Tan, RN Leong, AF Laguna, CA Ngo, A. Lao, D Amalin, and D Alvindia. A
Framework for Measuring Infestation Level on Cacao Pods. In 2016 IEEE Region
10 Symposium (TENSYMP), 384-389, Sanur, Bali Island, Indonesia, March 7-9 2016.
doi: 10.1109/TENCONSpring.2016.7519437.
A. Lao, V. Schmidt, Y. Schmitz, T.E. Willnow, and O. Wolkenhauer. Multi-
compartmental modeling of SORLA’s influence on amyloidogenic processing in
Alzheimer’s disease. BMC Syst. Biol., 6(1):74, June 2012. doi: 10.1186/1752-0509-
6-74. (BMC Systems Biology reflected in its latest impact factor of 2.980, according to the 2012
Journal Citation Reports [Thomson Reuters, 2013])
V. Schmidt, A. Lao, K. Baum, K. Rateitschak, Y. Schmitz, C. Munck Petersen, A.
Nykjaer, J. Wolf, O. Wolkenhauer, and T.E. Willnow. Quantitative modeling of
amyloidogenic processing and its influence by SORLA in Alzheimer’s disease.
EMBO J., 31(1):187 – 200, January 2012. doi: 10.1038/emboj.2011.352. (The EMBO
Journal reflected in its latest impact factor of 9.800, according to the 2012 Journal Citation Reports
[Thomson Reuters, 2013])
O. Wolkenhauer, A. Lao, S. Omholt, and H. Martens. Systems approaches in
molecular and cell biology: making sense out of data and providing meaning to
models. Proceedings of SPIE, 7343(1): 734318-734318-11, April 2009. doi:
10.1117/12.822742.

CONFERENCE PROCEEDINGS

P Chan, R Manero, M Te and A Lao. State Analysis of Three-node Network Motifs
using Boolean Model. De La Salle University Research Congress, 2020.
A Laron, DS Tan, NR Lim-Cheng, A Lao, and R Batista-Navarro. Corpus Annotation
of Biomedical Journals for a Machine Learning Approach to Automatic Relation
Extraction. Proceedings of the 17th Philippine Computing Science Congress,
University of San Carlos, Cebu, Philippines, March 16-18, 2017. ISSN 1908-1146.
JMC Edra, KD Talag, ML Enriquez, and A Lao. Systems Biology Approach of
Understanding the Effect of Raphanus sativus Extract on the Pathogenesis of
Chronic Myeloid Leukemia, Breast and Colon Cancer. De La Salle University
Research Congress, March 7-9 2016. ISSN No. 2449-3309, vol. 4.
DS Tan, RN Leong, AF Laguna, CA Ngo, A Lao, D Amalin, and D Alvindia. Method
for Measuring Infestation Level on Cacao Pods. De La Salle University Research
Congress, March 7-9 2016. ISSN No. 2449-3309, vol. 4.