Antimicrobial Compounds from Spondias purpurea
C. Ragasa, A. Poblete, and E. Navida (pp. 24-28)
Abstract
The dichloromethan, ethyl, acetate, ethanol, and water extracts of the freeze-dried bark of Spondias purpurea were tested for antimicrobial activities against seven microorganisms. Results of the study indicated that all the extracts at 30 micrograms have low antimicrobial activities against E. Coli, O. aeruginosa and T. mentagrophytes. The water and ethanol extracts showed low activity against C. albicans, while the ethyl acetate extract gave low activity against A. niger. All the extracts were inactive against S. Aureus and B. subtilis. The dichloromethane extract was fractionated by silica gel chromatography. It afforded 1, 2, and a mixture of hydrocarbons. Compounds 1 and 2 were identified by comparison of their HNMR spectral data with those of lutein and sistosterol, respectively. Sistosterol and the mixture of hydrocarbons were tested against the same microorganisms. Result of the study indicated that both compounds had low activity against E. Coli and P. aeruginosa at 30 micrograms and inactive against S. Aureus, B. subtilis, T. mentagrophytes and A. nigert. Sisterol gave low activity against C. albicans.