De La Salle University-Manila operates under the trimestral system. Its academic calendar consists of three (3) regular trimesters of about 14 weeks each, as follows:
| Term 1 | May (last full week) to August (end) |
| Term 2 | September (second week) to December (third week) |
| Term 3 | January (first week) to April (third week) |
Under this system, students should be able to finish their studies in less time than their counterparts in the semestral program. This is made possible by the more evenly paced schedule of subjects for each trimester.
| School Year 2008-2009 | Undergraduate Calendar (pdf) |
| School Year 2007-2008 | Undergraduate Calendar (pdf) |
| School Year 2006-2007 | Undergraduate Calendar (pdf) |
| School Year 2008-2009 | Graduate Studies Calendar (pdf) |
| School Year 2007-2008 | Graduate Studies Calendar (pdf) |
| School Year 2006-2007 | Gradaute Studies Calendar (pdf) |
| School Year 2008-2009 | Weekly Calendar (pdf) |
| School Year 2007-2008 | Weekly Calendar (pdf) |
| School Year 2006-2007 | Weekly Calendar (pdf) |