De La Salle University-Manila operates under the trimestral system. Its academic calendar consists of three (3) regular trimesters of about 14 weeks each, as follows:
| Term | Period |
| Term 1 | May (last full week) to August (end) |
| Term 2 | September (second week) to December (third week) |
| Term 3 | January (first week) to April (third week) |
Under this system, students should be able to finish their studies in less time than their counterparts in the semestral program. This is made possible by the more evenly paced schedule of subjects for each trimester.
| Academic Year | Revision Date |
| AY 2010-2011 (pdf/116kb) | As of 06 October 2009 |
| AY 2009-2010 (pdf/23kb) | As of 05 November 2009 |
| AY 2008-2009 (pdf/36kb) | As of 02 February 2009 |
| Academic Year | Revision Date |
| AY 2010-2011 (pdf/116kb) | As of 06 October 2009 |
| AY 2009-2010 (pdf/24kb) | As of 05 November 2009 |
| AY 2008-2009 (pdf/28kb) | As of 26 March 2009 |