| Granting Organization | Accredited/Assessed Unit | Status |
| Commission on Higher Education (CHED), Republic of the Philippines | De La Salle University | Autonomous Status Award of Distinction |
| Commission on Higher Education (CHED), Republic of the Philippines | Biology | Center of Excellence |
| Chemistry | Center of Excellence |
|
| Mathematics | Center of Excellence | |
| Physics | Center of Excellence |
|
| Information Technology Education | Center of Excellence | |
| Teacher Education | Center of Excellence |
|
| Chemical Engineering | Center of Development | |
| Civil Engineering | Center of Development | |
| Computer Engineering | Center of Development | |
| Electronics and Communications Engineering | Center of Development | |
| Mechanical Engineering | Center of Development | |
| Industrial Engineering | Center of Development | |
| Philippine Accrediting Association of Schools, Colleges and Universities (PAASCU) | ||
| Undergraduate Programs | Accountancy | Level III |
| Business and Economics | Level III | |
| Education | Level III | |
| Liberal Arts | Level III | |
| Science | Level III | |
| Computer Science | Level III | |
| Engineering (Civil, Industrial, ECE) |
Level IV | |
| Engineering (Chemical, Mechanical) |
Level III | |
| Graduate Programs | Education | Level II |
| Liberal Arts | Level II | |
| Science | Level II | |
| ASEAN University Network – AUN QA Assessment at Programme Level | Applied Corporate Management | Assessed November 2011 |
| Physics | Assessed November 2011 | |
| Software Technology | Assessed November 2011 | |
| Chemistry | Assessed November 2010 | |
| Literature | Assessed November 2010 | |
| Psychology | Assessed November 2010 | |
| Chemical Engineering | Assessed August 2008 | |
| Economics | Assessed August 2008 | |
The Commission on Higher Education (CHED) once again granted DLSU Manila a 5-Year Autonomous Status effective November 15, 2007 to November 14, 2012 (per CHED Memorandum order (CMO) No. 59 series of 2007). The selection and identification of higher educational institutions to be granted autonomous status are based on several criteria: commitment to excellence, long tradition of integrity and untarnished reputation; and sustainability and viability of operations. The indicators of the above criteria are measured by the number of Level IV and Level III programs of the institution, the number of CHED Centers of Excellence and Centers of Development, and international and national recognition for academic excellence.
The benefits given to institutions having autonomous status include exemption from issuance of Special Order (S.O.) for their graduates; priority in grant of subsidies and other financial incentives from CHED; privilege to prescribe their curricular programs; privilege to offer new courses/programs without seeking permit/authority from CHED; privilege to establish branches or satellite campuses without seeking government authority from CHED; authority to grant Honoris Causa to deserving individuals among others.
DLSU Manila was awarded Level IV accredited status by PAASCU making it the first university in the Philippines to be given the highest accreditation. PAASCU’s criteria for Level IV were met by DLSU Manila: 1) at least 75% of its programs have attained Level III status for a minimum of 10 years; 2) excellent outcomes in research as seen in the number, scope, and impact of scholarly publications in refereed national and international journals; 3) excellent outcomes in teaching and learning as proven in excellent performance of graduates and continuing assessment of student achievement; 4) excellent outcomes in community service and the impact of contributions to the economic and social upliftment , on both regional and national levels; 5) evidence of international linkages and consortia; and well developed planning processes which support quality assurance mechanisms.